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Heart Failure

Clinical Indications and Science Learning Series

Clinical Trials & Science

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Clinical Trials & Science

Episodes

Impact Of Rapid Up-Titration of Guideline-Directed Medical Therapies On Quality of Life: Insights From The STRONG-HF Trial
Impact Of Rapid Up-Titration of Guideline-Directed Medical Therapies On Quality of Life: Insights From The STRONG-HF Trial
9 min.
Introduction Of Guideline Directed Medical Therapy And Native Heart Recovery In Patients Supported By Impella 5.5
Introduction Of Guideline Directed Medical Therapy And Native Heart Recovery In Patients Supported By Impella 5.5
9 min.
Multicenter Development and Validation of a Supervised Machine Learning Risk Model to Predict Right Ventricular Failure Following Mechanical Circulatory Support: The STOP-RVF Score
Multicenter Development and Validation of a Supervised Machine Learning Risk Model to Predict Right Ventricular Failure Following Mechanical Circulatory Support: The STOP-RVF Score
12 min.
AI Assisted Identification of Super responders for Ultrafiltration can Reduce 90-Day Readmission Rates: Evidence from AVOID-HF Trial
AI Assisted Identification of Super responders for Ultrafiltration can Reduce 90-Day Readmission Rates: Evidence from AVOID-HF Trial
9 min.
Aquapheresis for Management of Decompensated Heart Failure: A Re-appraisal of AVOID-HF
Aquapheresis for Management of Decompensated Heart Failure: A Re-appraisal of AVOID-HF
10 min.
Serial Direct Sodium Removal in Patients with Heart Failure and Diuretic Resistance
Serial Direct Sodium Removal in Patients with Heart Failure and Diuretic Resistance
12 min.
A Novel Cardiac Scale and Algorithm for Detecting Worsening Congestion Preceding Heart Failure Events (HFEs): A Preliminary Analysis of the SCALE-HF 1 Study
A Novel Cardiac Scale and Algorithm for Detecting Worsening Congestion Preceding Heart Failure Events (HFEs): A Preliminary Analysis of the SCALE-HF 1 Study
10 min.
Cardiac Contractility Modulator as an Option for Advanced Heart Failure Patients Dependent on Low Dose inotropes
Cardiac Contractility Modulator as an Option for Advanced Heart Failure Patients Dependent on Low Dose inotropes
8 min.
Impact of Noninvasive, Low-Intensity Ultrasound Energy Delivery to the Kidney on Urine Output in Acutely Decompensated Heart Failure Patients
Impact of Noninvasive, Low-Intensity Ultrasound Energy Delivery to the Kidney on Urine Output in Acutely Decompensated Heart Failure Patients
10 min.
Acute and Chronic Outcomes in Early Feasibility Evaluation of Device-Based Thoracic Duct Decompression in Hospitalized Acute Decompensated Heart Failure Patients
Acute and Chronic Outcomes in Early Feasibility Evaluation of Device-Based Thoracic Duct Decompression in Hospitalized Acute Decompensated Heart Failure Patients
13 min.
Transcatheter pulmonary artery banding [PAB] for HFrEF: Initial results of invasive exercise hemodynamics and updates from the ongoing First-in-Human trial.
Transcatheter pulmonary artery banding [PAB] for HFrEF: Initial results of invasive exercise hemodynamics and updates from the ongoing First-in-Human trial.
10 min.
Initial Results from the First-in-Human Study of the Supira System
Initial Results from the First-in-Human Study of the Supira System
9 min.
Preliminary Results from the Early Feasibility Study of the FIRE1 System in Heart Failure Patients
Preliminary Results from the Early Feasibility Study of the FIRE1 System in Heart Failure Patients
9 min.
RECOVER-HF Pilot Study: Synchronized Diaphragmatic Stimulation for HFrEF Therapy
RECOVER-HF Pilot Study: Synchronized Diaphragmatic Stimulation for HFrEF Therapy
10 min.
Relationship of Patient Adherence to the Performance of a Remote Speech Analysis System to Detect Worsening Heart Failure Events in Ambulatory Heart Failure Patients
Relationship of Patient Adherence to the Performance of a Remote Speech Analysis System to Detect Worsening Heart Failure Events in Ambulatory Heart Failure Patients
13 min.
A Nationwide Study of a Remote Patient Monitoring and Intervention Program: The Impact on Heart Failure Clinical Outcomes and Healthcare Cost
A Nationwide Study of a Remote Patient Monitoring and Intervention Program: The Impact on Heart Failure Clinical Outcomes and Healthcare Cost
13 min.
Short-term Atrial Shunt Device-Induced Changes in Cardiac  Structure/Function and Risk of Subsequent Heart Failure Events: Findings from the REDUCE-LAP HF II Randomized Clinical Trial
Short-term Atrial Shunt Device-Induced Changes in Cardiac Structure/Function and Risk of Subsequent Heart Failure Events: Findings from the REDUCE-LAP HF II Randomized Clinical Trial
8 min.
Derivation and Validation of a Multicenter Model to Identify Candidates for Advanced HF Therapies with High Potential to Achieve post-LVAD Reverse Cardiac Remodeling
Derivation and Validation of a Multicenter Model to Identify Candidates for Advanced HF Therapies with High Potential to Achieve post-LVAD Reverse Cardiac Remodeling
12 min.
Endovascular Ablation of the Right Greater Splanchnic Nerve in Heart Failure with Preserved Ejection Fraction: One Year Results of the REBALANCE-HF Roll-in Cohort
Endovascular Ablation of the Right Greater Splanchnic Nerve in Heart Failure with Preserved Ejection Fraction: One Year Results of the REBALANCE-HF Roll-in Cohort
7 min.
Transcatheter Pulmonary Artery Banding In Chronic Heart Failure [HFrEF]: Results From the First-in-Human Study
Transcatheter Pulmonary Artery Banding In Chronic Heart Failure [HFrEF]: Results From the First-in-Human Study
8 min.
Wearable HF Monitoring Devices: Landscape Overview, Patient Indications, and Implementation Science
Wearable HF Monitoring Devices: Landscape Overview, Patient Indications, and Implementation Science
25 min.
The Conundrum of Clinical Trials in Cardiogenic Shock
The Conundrum of Clinical Trials in Cardiogenic Shock
16 min.
Acute Decompensated HF Trials: Who Should be Enrolled and What Should the Study Endpoints Be?
Acute Decompensated HF Trials: Who Should be Enrolled and What Should the Study Endpoints Be?
15 min.
Long-term Outcomes of Endovascular Baroreflex Amplification in Symptomatic Patients With HFrEF
Long-term Outcomes of Endovascular Baroreflex Amplification in Symptomatic Patients With HFrEF
11 min.
Transcatheter Pulmonary Artery Banding in Chronic Heart Failure: Results From an Early Feasibility Study
Transcatheter Pulmonary Artery Banding in Chronic Heart Failure: Results From an Early Feasibility Study
11 min.
Current Clinical Evidence Following TR Interventions
Current Clinical Evidence Following TR Interventions
20 min.
The PRELIEVE Trial: Responder Analysis in the HFpEF Subgroup Regarding Baseline PVR, Pacemaker and Pressure Gradients
The PRELIEVE Trial: Responder Analysis in the HFpEF Subgroup Regarding Baseline PVR, Pacemaker and Pressure Gradients
11 min.
No-Implant Interatrial Shunt for Heart Failure With Preserved and Mildly Reduced Ejection Fraction: Six-Month Outcomes From Multi-Center Pilot Feasibility Studies
No-Implant Interatrial Shunt for Heart Failure With Preserved and Mildly Reduced Ejection Fraction: Six-Month Outcomes From Multi-Center Pilot Feasibility Studies
12 min.
Pulmonary Artery Denervation: Innovative Pulmonary Hypertension Therapies
Pulmonary Artery Denervation: Innovative Pulmonary Hypertension Therapies
9 min.
Next Trials in LVAD Therapy
Next Trials in LVAD Therapy
8 min.
Baroreflex Activation Therapy (BAT) in Patients With Heart Failure and a Reduced Ejection Fraction (BeAT-HF): Long-Term Outcomes
Baroreflex Activation Therapy (BAT) in Patients With Heart Failure and a Reduced Ejection Fraction (BeAT-HF): Long-Term Outcomes
9 min.
Splanchnic Nerve Denervation for HFrEF and HFpEF
Splanchnic Nerve Denervation for HFrEF and HFpEF
8 min.
Cardiac Contractility Modulation for HFrEF and HFpEF:  Impulse Dynamics
Cardiac Contractility Modulation for HFrEF and HFpEF: Impulse Dynamics
9 min.
Mechanical Stimulation of the Carotid Sinus: MobiusHD
Mechanical Stimulation of the Carotid Sinus: MobiusHD
5 min.
Aortic Arch Simulation (Enopace)
Aortic Arch Simulation (Enopace)
8 min.
Vagal Nerve Stimulation (ANTHEM)
Vagal Nerve Stimulation (ANTHEM)
8 min.
Blood Volume Analysis Guided Heart Failure Management: A Pilot Randomized Controlled Trial
Blood Volume Analysis Guided Heart Failure Management: A Pilot Randomized Controlled Trial
9 min.
Exercise Capacity and Health-Related Quality of Life With Furoscix:  Data From the AT HOME Pilot Study
Exercise Capacity and Health-Related Quality of Life With Furoscix:  Data From the AT HOME Pilot Study
8 min.
Longer Term Effects of Hemodynamic Monitoring on Outcomes: A Combined Data Analysis of Patients with HFrEF in CHAMPION, GUIDE-HF, and LAPTOP-HF
Longer Term Effects of Hemodynamic Monitoring on Outcomes: A Combined Data Analysis of Patients with HFrEF in CHAMPION, GUIDE-HF, and LAPTOP-HF
11 min.
Impact of the V-Wave® Ventura® Interatrial Shunt Device on Right and Left Ventricular Structure and Function: Complete 12-Month Results of the RELIEVE-HF Roll-in Cohort
Impact of the V-Wave® Ventura® Interatrial Shunt Device on Right and Left Ventricular Structure and Function: Complete 12-Month Results of the RELIEVE-HF Roll-in Cohort
10 min.
Obesity in Heart Failure with Preserved Ejection Fraction: Insights from the REDUCE LAP-HF II Trial
Obesity in Heart Failure with Preserved Ejection Fraction: Insights from the REDUCE LAP-HF II Trial
10 min.
Influence of Body Surface Area, and Ventricular Dimensions on Impella 5.5 Outcomes
Influence of Body Surface Area, and Ventricular Dimensions on Impella 5.5 Outcomes
9 min.
Heart Failure Journal Editors' Forum: JACC: Basic to Translational Science
Heart Failure Journal Editors' Forum: JACC: Basic to Translational Science
7 min.
Heart Failure Journal Editors' Forum - Circ: Heart Failure
Heart Failure Journal Editors' Forum - Circ: Heart Failure
6 min.
Heart Failure Journal Editors' Forum: JACC - Heart Failure
Heart Failure Journal Editors' Forum: JACC - Heart Failure
7 min.
Heart Failure Journal Editors' Forum - JACC: Clinical Electrophysiology
Heart Failure Journal Editors' Forum - JACC: Clinical Electrophysiology
7 min.
Heart Failure Journal Editors' Forum: Structural Heart
Heart Failure Journal Editors' Forum: Structural Heart
7 min.
Pulmonary Artery Catheter Use in Patients with Heart Failure Cardiogenic Shock (HF-CS): An Analysis from the Cardiogenic Shock Working Group (CSWG)
Pulmonary Artery Catheter Use in Patients with Heart Failure Cardiogenic Shock (HF-CS): An Analysis from the Cardiogenic Shock Working Group (CSWG)
9 min.
Influence of Serum Potassium on the Decongestive Potential of Spironolactone: Insights from the ATHENA-HF Trial
Influence of Serum Potassium on the Decongestive Potential of Spironolactone: Insights from the ATHENA-HF Trial
9 min.
Clinical Profiling in Patients With HFpEF Phenotype Exhibiting Elevated Resting Supine and Normal Exercise Upright Pulmonary Capillary Wedge Pressures
Clinical Profiling in Patients With HFpEF Phenotype Exhibiting Elevated Resting Supine and Normal Exercise Upright Pulmonary Capillary Wedge Pressures
11 min.
Use of Remote Speech Analysis to Detect Worsening Heart Failure Events in Ambulatory Heart Failure Patients
Use of Remote Speech Analysis to Detect Worsening Heart Failure Events in Ambulatory Heart Failure Patients
11 min.
Physician-Directed Patient Self-Management in Heart Failure Using LA Pressure: Initial Insights From VECTOR-HF I & IIa Studies
Physician-Directed Patient Self-Management in Heart Failure Using LA Pressure: Initial Insights From VECTOR-HF I & IIa Studies
11 min.
Heart Failure Journal Editors' Forum: JCF
Heart Failure Journal Editors' Forum: JCF
7 min.
Heart Failure Journal Editors' Forum: Journal of Heart and Lung Transplant
Heart Failure Journal Editors' Forum: Journal of Heart and Lung Transplant
8 min.
Pros and Cons of the Win Ratio as the Primary Endpoint for Pivotal Heart Failure Trial
Pros and Cons of the Win Ratio as the Primary Endpoint for Pivotal Heart Failure Trial
10 min.
Strengths and Limitations of a Two-Phase (6-Month Intermediate Endpoints & 12-18 Month Mortality and Heart Failure Hospitalization) Design for Trials on Chronic Heart Failure Devices
Strengths and Limitations of a Two-Phase (6-Month Intermediate Endpoints & 12-18 Month Mortality and Heart Failure Hospitalization) Design for Trials on Chronic Heart Failure Devices
10 min.
Regulatory Aspects for Chronic Heart Failure Devices - FDA Perspective
Regulatory Aspects for Chronic Heart Failure Devices - FDA Perspective
10 min.
Clinically Meaningful and Practical Pivotal Trial Endpoints for Devices in Acute Decompensated Heart Failure
Clinically Meaningful and Practical Pivotal Trial Endpoints for Devices in Acute Decompensated Heart Failure
9 min.
Now is Not Soon Enough: Why Improving Patient Diversity in HF Trials is a Key Priority
Now is Not Soon Enough: Why Improving Patient Diversity in HF Trials is a Key Priority
10 min.
FDA Guidance on Meaningful Representation in Clinical Trials
FDA Guidance on Meaningful Representation in Clinical Trials
22 min.
Training Investigators to Advance Diversity and Inclusion
Training Investigators to Advance Diversity and Inclusion
9 min.
Recruitment Strategies for Vulnerable and Marginalized Trial Participants
Recruitment Strategies for Vulnerable and Marginalized Trial Participants
9 min.
The Leaders of the Pack: Why Improving Investigator Diversity in Heart Failure Trials is a Key Priority
The Leaders of the Pack: Why Improving Investigator Diversity in Heart Failure Trials is a Key Priority
17 min.
Regulatory Questions on Device Trials for Acute Decompensated Heart Failure - FDA Perspective
Regulatory Questions on Device Trials for Acute Decompensated Heart Failure - FDA Perspective
6 min.
Hot Topics on Regulatory Issues in Caridiogenic Shock - FDA Perspective
Hot Topics on Regulatory Issues in Caridiogenic Shock - FDA Perspective
8 min.
How Narrow or Broad Should Enrollment Criteria Be in Trials on Cardiogenic Shock  to Achieve Clinically Interpretable Results?
How Narrow or Broad Should Enrollment Criteria Be in Trials on Cardiogenic Shock to Achieve Clinically Interpretable Results?
7 min.
How Tightly Should Treatment Algorithms Be Prescribed in a Clinical Trial on Cardiogenic Shock? What Are The Key Treatment Protocol Elements?
How Tightly Should Treatment Algorithms Be Prescribed in a Clinical Trial on Cardiogenic Shock? What Are The Key Treatment Protocol Elements?
9 min.
Application of Exception from Informed Consent to a Multicenter Cardiogenic Shock Trial
Application of Exception from Informed Consent to a Multicenter Cardiogenic Shock Trial
9 min.
Debate: Revascularization in Chronic Heart Failure after REVIVED - Revascularize!
Debate: Revascularization in Chronic Heart Failure after REVIVED - Revascularize!
5 min.
Debate: Revascularization in Chronic Heart Failure after REVIVED - is GDMT enough?!
Debate: Revascularization in Chronic Heart Failure after REVIVED - is GDMT enough?!
4 min.
Latest Data From REVIVED
Latest Data From REVIVED
7 min.